association of cd58 polymorphism with multiple sclerosis and response to interferon ß therapy in a subset of iranian population
نویسندگان
چکیده
objective: multiple sclerosis (ms) is one of the leading neurodegenerative causes of physical disability world-wide. genetic aberrations of autoimmunity pathway components have been demonstrated to significantly influence ms development. cluster of differentiation 58 (cd58) is pertained to a group of genes which had been assayed in several recent association studies. given the significance of cd58 in modulation of t regulatory cells that control autoimmune responses, the present study was conducted to investigate the frequency of rs12044852 polymorphism and its effect on the outcome of interferon beta (ifn-β) therapy in a subset of iranian ms patients. materials and methods: two hundred ms patients and equal number of healthy controls were recruited to be genotyped in an experimental case-control based study through polymerase chain reaction using specific sequence primers (pcr-ssp). relapsing remitting multiple sclerosis (rrms) patients administered ifn-β therapy were followed up with clinical visits every three months up to two years. the mean of multiple sclerosis severity score (msss) and expanded disability status scale (edss) were measured to monitor the change in severity of ms in response to ifn-β therapy. pearson’s chi-square and analysis of variance (anova) tests were the main statistical methods used in this study. results: strong association was found between the cc genotype and onset of ms (p=0.001, or=2.22). however, there was no association between rs12044852 and various classifications and severity of ms. pharmacogenetics-based analysis indicated that carriers of cc genotype had the highest msss score compared to others, implying a negative impact of rs12044852 on response to ifn-β t herapy. conclusion: taken together, our findings revealed the critical effect of rs12044852 polymorphism of cd58 on the progression of ms disease. this indicates that genotyping of ms patients may expedite achieving personalized medical management of ms patients.
منابع مشابه
Association of CD58 Polymorphism with Multiple Sclerosis and Response to Interferon ß Therapy in A Subset of Iranian Population
OBJECTIVE Multiple sclerosis (MS) is one of the leading neurodegenerative causes of physical disability world-wide. Genetic aberrations of autoimmunity pathway components have been demonstrated to significantly influence MS development. Cluster of Differentiation 58 (CD58) is pertained to a group of genes which had been assayed in several recent association studies. Given the significance of CD...
متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولAssociation of two polymorphisms in MSH2 and XRCC1 genes with multiple sclerosis in Iranian population
Introduction: To protect genomes of all organisms from internal and external damages and maintain the genome integrity and the continuity of life, repair system has been developed in all living cells. Defects in repair system are responsible for various kinds of disease including cancers and neurodegenerative diseases such as Multiple sclerosis (MS). The relationship between various compone...
متن کاملAssociation of CD24V/V Genotype with Susceptibility and Progression of Multiple Sclerosis in Iranian Population
A single nucleotide polymorphism (SNP) in CD24 has been associated with multiple sclerosis (MS) in a population based study. This SNP results in the replacement of alanine (CD24A) by valine (CD24V) at amino acid 57 in the resulting polypeptide chain. In the current study, the genotyping of this SNP and its contribution to MS in 217 patients and 200 healthy individuals of an Iranian population w...
متن کاملAssociation of Warfarin Therapy with APOE and VKORC1 Genes Polymorphism in Iranian Population
Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
cell journalجلد ۱۶، شماره ۴، صفحات ۵۰۶-۵۱۳
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023